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Published on: January 5, 2024
Diabetes is associated with increased risk of venous thromboembolism: a systematic review and meta-analysis
Jing Bai1, Xiang Ding1, Xiaohui Du1
1Department of Cardiology of PLA 161 Hospital, Wuhan 430030, China.
Aims:
Increasing evidence suggests an association between diabetes and risk of venous thromboembolism (VTE); however, the results are inconsistent. We conducted a systematic review and meta-analysis of all epidemiological evidence to clarify association of diabetes with risk of VTE.
Methods:
We searched MEDLINE and EMBASE to retrieve all relevant articles. Pooled effect estimates were calculated through a random-effects model.
Results:
Sixteen articles involving 803,627,121 participants and 10,429,227 VTE patients were included. Pooled analysis of all evidence suggested that diabetes was associated with increased risk of VTE (HR, 1.35; 95%CI, 1.17-1.55; p=2.92*10(-5)), with evidence of small-study effect (p=0.024) and heterogeneity (I(2)=87.1%, p<0.001). However, when analysis was restricted to high quality cohort studies, the association remained significantly (HR, 1.36; 95%CI 1.11-1.68; p=0.004), with no evidence of publication bias (p=0.192) and heterogeneity (I(2)=23.2%, p=0.245).
Conclusions:
Diabetes is associated with increased risk of VTE, which may have implications for the primary and secondary prevention of VTE.
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