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Stereotactic radiosurgery for intraventricular brain metastases
Benjamin Farnia1, K Ranh Voong, Paul D Brown
1Departments of 1 Radiation Oncology.
Journal of Neurosurgery
|December 2, 2014
Summary
Stereotactic radiosurgery (SRS) offers high local control for intraventricular metastases, demonstrating its efficacy as a non-surgical treatment option. This study highlights SRS
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Previous surgical management of lateral ventricle metastases reported a 69% crude local control rate.
- Intraventricular metastases present unique treatment challenges.
- Stereotactic radiosurgery (SRS) is an alternative treatment modality.
Purpose of the Study:
- To evaluate the institutional experience with SRS for intraventricular metastases.
- To compare SRS outcomes with previously reported surgical management outcomes.
- To assess the efficacy and toxicity of SRS in this patient population.
Main Methods:
- Retrospective review of an institutional SRS database (June 2009 - October 2013).
- Identified 25 patients with 30 intraventricular metastases.
- Assessed endpoints including local control, progression-free survival, and overall survival.
Main Results:
- Crude local control rate of 93.3% achieved with SRS.
- 6-month and 1-year locoregional control rates were 85.2% and 56.2%, respectively.
- Median overall survival post-SRS was 11.6 months; 7 (28%) patients experienced disease dissemination.
Conclusions:
- SRS provides excellent local control for intraventricular metastases.
- SRS demonstrates acceptable treatment-related toxicity.
- SRS supports consideration as a non-surgical treatment for intraventricular metastases.
