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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Sanger Sequencing01:57

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Related Experiment Video

Updated: Apr 20, 2026

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
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Novel biosensing methodologies for improving the detection of single nucleotide polymorphism.

Kai Chang1, Shaoli Deng1, Ming Chen1

  • 1Department of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.

Biosensors & Bioelectronics
|December 2, 2014
PubMed
Summary

Biosensors offer a sensitive, rapid, and cost-effective method for identifying single nucleotide polymorphisms (SNPs). These advanced techniques are crucial for understanding genetic disease susceptibility and personalizing medical treatments.

Keywords:
BiosensorDetectionOligonucleotideSingle-nucleotide polymorphism

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Area of Science:

  • Biotechnology
  • Genetics
  • Molecular Biology

Background:

  • Increasing sequence data identify more single nucleotide polymorphisms (SNPs).
  • SNPs are linked to individual disease susceptibility and varied treatment responses.
  • There is a need for efficient and affordable SNP identification methods.

Purpose of the Study:

  • To review SNP genotyping strategies utilizing biosensors.
  • To discuss the advantages, limitations, and future of biosensor-based SNP detection.

Main Methods:

  • Review of biosensing strategies for SNP genotyping.
  • Focus on methods including nucleic acid analogs, ligation, single base extension, mismatch binding proteins, molecular beacons, rolling circle amplification, and strand-displacement amplification.

Main Results:

  • Biosensors integrate biological specificity with physical sensor sensitivity for SNP detection.
  • Various biosensor-based strategies offer distinct advantages for genotyping.
  • Current limitations and future trends in biosensor development for SNP analysis were discussed.

Conclusions:

  • Biosensing techniques present a promising alternative for SNP detection.
  • This technology can advance genetic disease diagnosis and tailored treatment design.