Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

15.7K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.7K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.8K
3.8K
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

11.2K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
11.2K
Translation01:31

Translation

23.4K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
23.4K
Translation01:31

Translation

162.9K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
162.9K
Leaky Scanning02:28

Leaky Scanning

5.9K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SPHN - The Swiss Personalized Health Network Initiative.

Studies in health technology and informatics·2020
Same author

Chemical Landmark 2013 - designation of Lonza, a pioneer of chemistry in upper Valais.

Chimia·2014
Same author

Bioinspired surfaces against bacterial infections.

Chimia·2013
Same author

Bioinspired, releasable quorum sensing modulators.

Chemical communications (Cambridge, England)·2012

Related Experiment Video

Updated: Apr 20, 2026

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.6K

Translational science: a catalyst for real world applications?

Adrien K Lawrence1

  • 1Swiss Academy of Sciences (SCNAT), Schwarztorstrasse 9, CH-3007 Bern, Switzerland. chemistry@scnat.ch.

Chimia
|December 2, 2014
PubMed
Summary

Translational science bridges research and real-world applications. This study explores its applicability beyond healthcare to address broader societal challenges through empirical knowledge.

Area of Science:

  • Exploration of translational science principles.
  • Interdisciplinary research and innovation.

Background:

  • Scientific knowledge relies on empirical evidence and replicability.
  • Translational science links research findings to practical applications.
  • Societal challenges necessitate effective knowledge translation.

Purpose of the Study:

  • To investigate the potential application of translational science outside of healthcare research.
  • To assess the adaptability of translational science models in diverse research settings.
  • To examine the role of the science-policy interface in broader translational efforts.

Main Methods:

  • Conceptual analysis of translational science frameworks.
  • Literature review on interdisciplinary research applications.

More Related Videos

Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K
Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
14:29

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells

Published on: December 25, 2021

5.0K

Related Experiment Videos

Last Updated: Apr 20, 2026

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.6K
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K
Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
14:29

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells

Published on: December 25, 2021

5.0K
  • Examination of case studies in non-healthcare sectors.

    • Main Results:

    • Translational science principles demonstrate potential applicability in various research fields.
    • Adaptation of models requires consideration of specific sector contexts.
    • The science-policy interface is critical for successful translation across domains.

    Conclusions:

    • Translational science offers a valuable framework for addressing societal issues beyond healthcare.
    • Further research is needed to refine models for non-health-related applications.
    • Effective knowledge translation requires tailored approaches and stakeholder engagement.