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Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Published on: May 31, 2024

Bioinspired, releasable quorum sensing modulators.

José Gomes1, Alexander Grunau, Adrien K Lawrence

  • 1Department of Chemistry, NCCR Chemical Biology, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.

Chemical Communications (Cambridge, England)
|November 22, 2012
PubMed
Summary
This summary is machine-generated.

Researchers created natural product hybrids that activate bacterial communication (quorum sensing) when slowly released from titanium dioxide surfaces. This immobilization method offers a novel approach for controlling bacterial behavior.

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Area of Science:

  • Biomaterials Science
  • Synthetic Chemistry
  • Microbiology

Background:

  • Quorum sensing (QS) is a cell-to-cell communication mechanism crucial for bacterial behavior and virulence.
  • Acyl-homoserine lactones (AHLs) are common QS signal molecules in Gram-negative bacteria.
  • Nitrodopamine derivatives have shown potential in various biomedical applications.

Purpose of the Study:

  • To synthesize novel natural product hybrids combining AHL and nitrodopamine functionalities.
  • To immobilize these hybrids onto biocompatible titanium dioxide (TiO2) surfaces.
  • To evaluate the efficacy of immobilized hybrids as quorum sensing activators.

Main Methods:

  • Synthesis of hybrid molecules integrating acyl-homoserine lactone and nitrodopamine moieties.
  • Immobilization onto TiO2 surfaces via a simple dip-and-rinse technique.
  • Assessment of quorum sensing activation in Pseudomonas strains using the immobilized hybrids.

Main Results:

  • Successful synthesis and characterization of the natural product hybrids.
  • Effective immobilization of hybrids onto TiO2 surfaces, confirmed by surface analysis.
  • Demonstrated potent activation of quorum sensing in Pseudomonas species.
  • Observed slow release of active compounds from the TiO2 surface, leading to sustained QS activation.

Conclusions:

  • The developed method allows for the straightforward immobilization of functional natural product hybrids onto TiO2.
  • The immobilized hybrids serve as effective and sustained activators of bacterial quorum sensing.
  • This approach offers a promising strategy for modulating bacterial communication and behavior in various applications.