Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

579
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
579
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

436
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
436
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

477
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
477
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

393
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
393
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of O-antigen due to <i>wbbL</i> mutations is common and associated with increased mortality in <i>Escherichia coli</i> bloodstream infections.

Science advances·2026
Same author

Malaria Risk among Internally Mobile Individuals and Heterogeneous Mobility Patterns in Two Hypoendemic Communities: Implications for Malaria Elimination in the Peruvian Amazon.

medRxiv : the preprint server for health sciences·2026
Same author

Understanding <i>Plasmodium vivax</i> recurrent infections using an amplicon deep sequencing assay, identity-by-descent and model-based classification.

iScience·2026
Same author

Words and Worms: The Nosology of Strongyloidiasis.

The American journal of tropical medicine and hygiene·2026
Same author

Isolated Nausea and Pretibial Rash in a Returning Traveler: Forme Fruste of Leptospirosis.

The American journal of tropical medicine and hygiene·2026
Same author

A Triple-Modality Peptide-Antibiotic-Phage Therapy Eradicates Multidrug-Resistant <i>Serratia marcescens</i> Biofilms.

bioRxiv : the preprint server for biology·2026
Same journal

Five-Year Risk of CIN3+ After CIN1 Biopsy in a Norwegian Screening Setting: Comparison of CIN1 Diagnosed in a Single Calendar Year and in Two Consecutive Calendar Years.

Pathogens (Basel, Switzerland)·2026
Same journal

Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.

Pathogens (Basel, Switzerland)·2026
Same journal

Anti-<i>Borrelia</i> IgG Seropositivity Among Hemodialysis Patients with Chronic Kidney Disease of Unknown Etiology: A Preliminary Case-Control Study from Northern Türkiye.

Pathogens (Basel, Switzerland)·2026
Same journal

Molecular Characterization of Hemotropic <i>Mycoplasma</i> spp. From Bats (Chiroptera) in the Northern Pantanal, Brazil.

Pathogens (Basel, Switzerland)·2026
Same journal

Characterization of Durum-Einkorn Amphiploids for Introgression of Powdery Mildew Resistance from Einkorn into Common Wheat.

Pathogens (Basel, Switzerland)·2026
Same journal

Human Orthohantavirus Infections: A Narrative Review.

Pathogens (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance
06:05

Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance

Published on: June 14, 2024

1.7K

Leptospiral pathogenomics.

Jason S Lehmann1, Michael A Matthias2, Joseph M Vinetz3

  • 1Division of Infectious Diseases, Department of Medicine, University of California San Diego, School of Medicine, La Jolla, CA 92093-0741, USA. jslehman@ucsd.edu.

Pathogens (Basel, Switzerland)
|December 2, 2014
PubMed
Summary
This summary is machine-generated.

Leptospirosis research is advancing with pathogenomics, a new approach using genome data to identify bacterial virulence factors. This helps understand and combat this global zoonotic disease.

More Related Videos

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

5.5K
High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection
11:50

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

Published on: December 18, 2017

9.2K

Related Experiment Videos

Last Updated: Dec 20, 2025

Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance
06:05

Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance

Published on: June 14, 2024

1.7K
Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

5.5K
High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection
11:50

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

Published on: December 18, 2017

9.2K

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Leptospirosis is a significant global zoonotic disease caused by *Leptospira* bacteria.
  • Research into *Leptospira* pathogenesis is challenging due to slow growth and limited genetic tools.
  • Advances in sequencing technologies have spurred *Leptospira* genome sequencing and functional genomics.

Purpose of the Study:

  • To review functional genomics approaches for studying *Leptospira* virulence.
  • To highlight the role of pathogenomics in understanding *Leptospira* pathogenesis.
  • To leverage data from the global *Leptospira* Genome Project.

Main Methods:

  • Utilizing a pathogenomics approach, combining pan-genomic analysis with sequencing of attenuated strains.
  • Applying functional genomics to infer virulence factors.
  • Leveraging data from the global *Leptospira* Genome Project.

Main Results:

  • Functional inference of *Leptospira* virulence factors has been achieved through pathogenomics.
  • The global *Leptospira* Genome Project provides a foundation for future research.
  • Pathogenomics enables deeper understanding of bacterial pathogenesis.

Conclusions:

  • Functional genomics and pathogenomics are crucial for advancing *Leptospira* research.
  • Understanding virulence factors is key to combating leptospirosis.
  • The *Leptospira* Genome Project offers a roadmap for future studies.