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Usefulness of S100A12 as a prognostic biomarker for adverse events in patients with heart failure

Yun-Yun He1, Wei Yan2, Chun-Lei Liu2

  • 1Department of Cardiology, Chinese PLA General Hospital, Beijing China; School of Medicine, Nankai University, Tianjin China.

Clinical Biochemistry
|December 2, 2014
PubMed

Insights

Elevated S100A12 protein levels are linked to chronic heart failure (CHF) and predict major cardiovascular events (MCE) in patients. This finding highlights S100A12 as a potential biomarker for CHF prognosis.

Area of Science:

  • Biochemistry
  • Cardiology
  • Immunology

Background:

  • S100A12 protein is implicated in granulocyte-mediated inflammation.
  • Chronic heart failure (CHF) is a significant cardiovascular condition with ongoing research into its underlying mechanisms and biomarkers.

Purpose of the Study:

  • To investigate the association between S100A12 protein levels and chronic heart failure (CHF).
  • To determine if S100A12 can serve as a predictive biomarker for major cardiovascular events (MCE) in CHF patients.

Main Methods:

  • Plasma S100A12 and high-sensitivity C-reactive protein (hs-CRP) levels were measured in 177 CHF patients and 66 controls.
  • CHF patients were followed for 18 months to record major cardiovascular events (MCE), including cardiac death and heart failure rehospitalization.
  • Statistical analyses, including correlation and Cox regression, were employed to assess relationships and predictive value.

Main Results:

  • Plasma S100A12 levels were significantly elevated in CHF patients compared to controls (P<0.001).
  • S100A12 levels positively correlated with hs-CRP (r=0.316, P<0.001).
  • Higher S100A12 levels were associated with an increased risk of MCE in CHF patients, with S100A12 identified as an independent risk factor (P=0.009).

Conclusions:

  • S100A12 is a potential biomarker for chronic heart failure (CHF).
  • S100A12 levels provide valuable information for predicting major cardiovascular events (MCE) in patients with CHF.
Abstract

Keywords:
Heart failureInflammationS100A12hs-CRP

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