Comparison of plasma exchange procedures using three apheresis systems

Area of Science:

• Nephrology
• Critical Care Medicine
• Medical Device Technology

Background:

• A new protocol allows the Amicus separator to perform plasma exchange (PE).
• Plasma exchange is a crucial therapeutic apheresis procedure.
• Comparing different apheresis devices is essential for optimizing patient care.

Purpose of the Study:

• To compare the plasma removal efficiency (PRE) of the Amicus, Optia, and Spectra devices during PE.
• To evaluate differences in anticoagulant and calcium-magnesium solution usage.
• To assess the impact of PE on laboratory parameters and safety.

Main Methods:

• Retrospective review of patients undergoing PE with Amicus, Optia, or Spectra devices.
• Data collection included PRE, infused volumes, and pre/post-PE laboratory values.
• Analysis of severe adverse events (AEs) associated with each device.

Main Results:

• Plasma removal efficiency (PRE) was 79.8% (Amicus), 82.9% (Optia), and 70.4% (Spectra).
• Amicus used significantly less anticoagulant (542 mL) than Optia (687 mL).
• Significant differences observed in Ca-Mg infusion volumes and changes in ionic calcium and sodium levels.

Conclusions:

• The Amicus device is effective for PE, with PRE comparable to the Optia.
• Both Amicus and Optia showed superior PRE compared to the Spectra device.
• The Amicus demonstrated a favorable anticoagulant profile during PE procedures.