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Dopamine and memory function in Parkinson's disease.

E Mohr1, G Fabbrini, J Williams

  • 1Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1989
PubMed
Summary
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Levodopa treatment in Parkinson's disease patients improved delayed recall of complex verbal materials when medicated ("on") compared to when unmedicated ("off"). These cognitive changes associated with dopaminomimetic therapy appear to be task-specific.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • Motor fluctuations in Parkinson's disease (PD) complicate dopaminomimetic therapy.
  • Cognitive effects of dopaminomimetic therapy in PD are not fully understood.

Purpose of the Study:

  • To evaluate the impact of levodopa treatment on attention and memory in Parkinson's disease patients.
  • To determine if cognitive performance differs between medication "on" and "off" states in PD.

Main Methods:

  • Neuropsychological testing of PD patients in both levodopa/carbidopa "on" and "off" states.
  • Assessment of attention, memory acquisition, and memory retrieval tasks.

Main Results:

  • Patients performed significantly better on delayed recall of complex verbal materials when "on" levodopa compared to "off".

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  • No substantial cognitive differences were found based on the timing of levodopa/carbidopa administration or withholding between task phases.

    • Conclusions:

    • Levodopa therapy in Parkinson's disease is associated with subtle, task-specific cognitive changes.
    • Delayed verbal recall is a cognitive domain sensitive to dopaminomimetic therapy fluctuations in PD.