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Updated: Apr 20, 2026
13:50
Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
12.8K
Microbiome in human immunodeficiency virus infection.
January T Salas1, Theresa L Chang1
1Department of Microbiology and Molecular Genetics, Public Health Research Institute, Rutgers-New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA.
Clinics in Laboratory Medicine
|December 3, 2014
Summary
The human immunodeficiency virus (HIV) interacts with the body's microbiome, particularly at mucosal tissues. Understanding this relationship may lead to improved HIV prevention and treatment strategies.
Area of Science:
- Microbiology
- Virology
- Immunology
Background:
- Primary human immunodeficiency virus (HIV) infection occurs at mucosal sites, indicating a significant role for the microbiome.
- HIV infection is linked to alterations in the microbiome and immune system activation, potentially influencing disease progression.
Purpose of the Study:
- To review the current understanding of the microbiome's role in HIV infection across various mucosal compartments.
- To highlight how exploring the microbiome-HIV interaction can inform new HIV prevention and treatment approaches.
Main Methods:
- This review synthesizes findings from studies utilizing high-throughput sequencing and bioinformatics.
- Focuses on research examining microbial communities (bacteria, viruses, fungi) in the context of HIV infection.
Main Results:
- HIV infection is associated with significant shifts in the host microbiome.
- Microbiome alterations and immune activation are key factors in HIV disease progression.
Conclusions:
- The interplay between the microbiome and HIV at mucosal sites is critical.
- Further research into the microbiome-HIV relationship offers potential for novel therapeutic and preventative interventions.
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