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Updated: Apr 20, 2026

Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
Toxic-metabolic, nutritional, and medicinal-induced disorders of cerebellum
Nadejda Alekseeva1, Jeanie McGee2, Roger E Kelley3
1Department of Psychiatry, Overton Brooks VA Medical Center, 510 East Stoner Avenue, Shreveport, LA 71101, USA.
Abstract:
The human cerebellum is composed of 2 hemispheres and a narrow medial section (vermis). Three pairs of dense fiber bundles (peduncles) connect the cerebellum to the brain. The cerebellum possesses widespread outgoing connections. Insult can result in neurologic deficits, including ataxia, hypotonia, dysarthria, and ocular motility problems. It is particularly susceptible to toxic effects of metabolic and medicinal insults. The cerebellum is potentially sensitive to alcohol, drug exposure, illicit drugs, and environmental poisons (mercury, lead, manganese, and toluene/benzene derivatives). The astute clinician must be aware of the multiple potential factors that can adversely affect cerebellar function.
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