Jove
Visualize
Contact Us

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

1.5K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.5K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

814
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
814
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

889
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
889
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

1.1K
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.1K
Introspection01:29

Introspection

431
Introspection, long upheld as a reliable route to self-knowledge, involves examining one's thoughts, emotions, and mental processes. It underpins many psychological practices, from mindfulness meditation to psychotherapy and self-help strategies. However, empirical evidence challenges the accuracy of introspection as a means of understanding oneself.Limitations of Introspective InsightSeminal work by Nisbett and Wilson demonstrated that individuals are frequently unaware of the true causes...
431

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From microstates to macroscales: A critical review of maximum entropy modeling and energy landscape analysis in functional MRI.

Neuroscience and biobehavioral reviews·2026
Same author

Daily-Life Peer Interactions Among Adolescents at Familial High-Risk for Psychosis: An Ecological Momentary Assessment (EMA) Study.

Child psychiatry and human development·2026
Same author

Anterior insula reactivity to loss moderates the association between trait impulsivity and future suicidal ideation in adolescents.

Developmental cognitive neuroscience·2026
Same author

Bupropion-Memantine Combination in the Treatment of Major Depressive Disorder and Treatment-Resistant Depression.

Human psychopharmacology·2026
Same author

Smartphone app-based Integrated Cognitive Control Training for Anxiety Disorders: Study protocol for a Multi-site Randomized Control Trial.

medRxiv : the preprint server for health sciences·2026
Same author

From microstates to macroscales: A Critical Review of Maximum Entropy Modeling and Energy Landscape Analysis in functional MRI.

Research square·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 20, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.8K

Insight and neurocognitive functioning in bipolar subjects.

Mujeeb U Shad1, Konasale Prasad2, Steven D Forman3

  • 1Mental Illness, Research, Educational and Clinical Center VA Pittsburgh Healthcare System, Pittsburgh, PA.

Comprehensive Psychiatry
|December 3, 2014
PubMed
Summary

Individuals with bipolar disorder generally have good insight into their illness, unlike those with schizophrenia. Mania symptoms, not alcoholism or cognitive issues, were linked to awareness levels in this study.

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 20, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.8K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.4K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Insight into mental illness impacts treatment outcomes.
  • Research on insight is limited in bipolar disorder compared to schizophrenia.
  • This study investigates insight in bipolar disorder using the Scale to Assess Unawareness of Mental Disorder (SUMD).

Purpose of the Study:

  • To evaluate insight in individuals with bipolar disorder.
  • To explore associations between insight and neurocognitive function, brain structure (frontal lobes, hippocampus), psychiatric symptoms, and comorbid alcoholism.
  • To test the hypothesis that unawareness is linked to cognitive, structural, and comorbidity factors.

Main Methods:

  • 33 individuals with DSM-IV diagnosed bipolar disorder were assessed.
  • Procedures included the SUMD, quantitative MRI, neurocognitive tests, Brief Psychiatric Rating Scale, and Young Mania Rating Scale.
  • Data analyzed using t tests and linear multiple regression.

Main Results:

  • Most participants showed awareness of their mental disorder.
  • No significant differences in insight were found between those with and without comorbid alcoholism.
  • Mania symptom severity (irritability, sleep disturbance) was significantly associated with higher awareness (r(2)=.632, p<.05).

Conclusions:

  • Unlike schizophrenia, most bipolar disorder patients in this sample demonstrated good insight.
  • Comorbid alcoholism, cognitive dysfunction, and reduced gray matter were not associated with unawareness.
  • Mania symptoms, rather than other factors, significantly correlated with the level of insight in bipolar disorder.