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Updated: Apr 20, 2026
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Hepatitis B virus infection and the risk of male infertility: a population-based analysis
Fu-Hsiung Su1, Shih-Ni Chang2, Fung-Chang Sung3
1Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Objective:
To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.
Design:
A nationwide, population-based cohort study.
Setting:
Not applicable.
Patient(S):
Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).
Intervention(S):
None.
Main Outcome Measure(S):
Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.
Result(S):
The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.
Conclusion(S):
The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
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