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The fentanyl story.

Theodore H Stanley1

  • 1Department of Anesthesiology, School of Medicine, University of Utah, 30 North 1900 East 3C444, Salt Lake City, UT 84132. Theodore.stanley@hsc.utah.edu

The Journal of Pain
|December 3, 2014
PubMed
Summary
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Fentanyl is a widely used opioid for intraoperative analgesia and chronic pain management due to its favorable safety profile and cost-effectiveness. Its various formulations offer effective pain relief for diverse patient needs.

Area of Science:

  • Anesthesiology
  • Pain Management
  • Pharmacology

Background:

  • Fentanyl, an opioid analgesic, has been clinically utilized for over five decades.
  • It is a primary choice for intraoperative analgesia and managing chronic pain conditions.
  • Transmucosal fentanyl formulations have been developed for breakthrough pain management.

Purpose of the Study:

  • To elucidate the reasons behind fentanyl's widespread importance in contemporary pain treatment.
  • To analyze the clinical and economic factors contributing to fentanyl's popularity.

Main Methods:

  • Review of clinical data and market trends related to fentanyl use.
  • Analysis of fentanyl's pharmacological and pharmacokinetic properties.
  • Assessment of economic factors in fentanyl synthesis and preparation.

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Main Results:

  • Fentanyl exhibits minimal cardiovascular effects and does not elevate plasma histamine levels.
  • It offers a relatively short onset and duration of action, suitable for various pain types.
  • Fentanyl is easy and cost-effective to synthesize and prepare for market availability.

Conclusions:

  • Fentanyl's clinical significance is attributed to its favorable safety profile, efficacy, and economic advantages.
  • Familiarity among clinicians in pain and perioperative medicine further contributes to its widespread adoption.
  • Fentanyl remains a cornerstone in modern pain management strategies.