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Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Dietary models of insulin resistance
James Deer1, Juraj Koska1, Marlies Ozias1
1Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892.
Abstract:
Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained. Dietary macronutrient composition has been examined in a number of articles, and diets enriched in saturated fatty acids, and possibly in fructose, appear to be most consistently associated with the development of insulin resistance. However, mechanistic insights into the metabolic effects of such diets are lacking, and merit further study.
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