Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

66
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
66
Microbiome of the Eye01:22

Microbiome of the Eye

62
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
62
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

118
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
118
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

172
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
172
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

5.0K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
5.0K
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

256
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of allogeneic ocular surface stem cell transplantation.

Frontiers in ophthalmology·2026
Same author

Current Practices, Evolving Techniques, and Immunologic Challenges in Living and Deceased Donor Limbal Stem Cell Transplantation.

American journal of ophthalmology·2026
Same author

Neurotrophic Keratopathy: Current Concepts, Management, and Emerging Treatments.

Cornea·2026
Same author

Lotilaner ophthalmic solution 0.25% in the treatment of <i>Demodex</i> blepharitis: A case report.

SAGE open medical case reports·2026
Same author

Representation of Topical Corticosteroid Withdrawal and Steroid Phobia on TikTok and YouTube Shorts: A Mixed-Methods Content Analysis.

The Australasian journal of dermatology·2026
Same author

Tacrolimus-Related Kidney Function Change in Ocular Stem Cell Transplantation.

Cornea·2026

Related Experiment Video

Updated: Apr 20, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.3K

Current knowledge about and recommendations for ocular methicillin-resistant Staphylococcus aureus.

Francis S Mah, Richard Davidson, Edward J Holland

    Journal of Cataract and Refractive Surgery
    |December 3, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Methicillin-resistant Staphylococcus aureus (MRSA) is a growing threat after eye surgeries like cataract surgery and keratectomy. This review addresses the increasing challenge of ocular MRSA infections and suggests evidence-based recommendations for management.

    More Related Videos

    Conjunctival Commensal Isolation and Identification in Mice
    07:52

    Conjunctival Commensal Isolation and Identification in Mice

    Published on: May 1, 2021

    5.1K
    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
    12:18

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

    Published on: February 9, 2011

    23.8K

    Related Experiment Videos

    Last Updated: Apr 20, 2026

    Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
    14:04

    Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

    Published on: May 8, 2013

    25.3K
    Conjunctival Commensal Isolation and Identification in Mice
    07:52

    Conjunctival Commensal Isolation and Identification in Mice

    Published on: May 1, 2021

    5.1K
    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
    12:18

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

    Published on: February 9, 2011

    23.8K

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Microbiology

    Background:

    • Staphylococcus aureus is a common cause of post-surgical ocular infections.
    • Methicillin-resistant Staphylococcus aureus (MRSA) infections are increasingly reported following ophthalmic procedures.
    • MRSA is a significant global pathogen, particularly concerning in the context of eye surgery.

    Purpose of the Study:

    • To review the current literature on ocular MRSA infections.
    • To describe the challenges posed by MRSA in ophthalmic settings.
    • To provide evidence-based recommendations for the identification, treatment, and reduction of ocular MRSA.

    Main Methods:

    • Literature review of current medical publications.
    • Evidence-based analysis of existing data.
    • Synthesis of findings to formulate recommendations.

    Main Results:

    • Staphylococcus aureus is a leading cause of infection after procedures like cataract surgery, LASIK, and PRK.
    • MRSA infections are increasingly prevalent in various ocular surgical wounds, including corneal and transplantation procedures.
    • The global prevalence of MRSA is rising, posing a significant challenge in ophthalmology.

    Conclusions:

    • Ocular MRSA infections represent a growing and serious clinical problem.
    • Effective strategies are needed to combat the increasing prevalence of MRSA in eye care.
    • Evidence-based recommendations are crucial for managing and potentially reducing ocular MRSA infections.