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Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora
Chew-Yan Gan1, K Yoganathan2, Kae-Shin Sim3
1University Malaysia of Computer Science and Engineering, Jalan Alamanda 2, Precint 1, 62000 Putrajaya, Malaysia.
Abstract:
Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.
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