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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis improvement after bariatric surgery.

Héctor Romero-Talamás1, Ali Aminian1, Ricard Corcelles1

  • 1Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio.

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Bariatric surgery improved psoriasis in nearly 40% of obese patients, with outcomes linked to weight loss and procedure type. This suggests bariatric surgery can be an effective treatment for psoriasis in obese individuals.

Keywords:
Bariatric surgeryGLP-1Gastric bypassMetabolic syndromePsoriasis

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Area of Science:

  • Dermatology
  • Bariatric Surgery
  • Metabolic Syndrome

Background:

  • Psoriasis is a chronic inflammatory skin condition linked to obesity and metabolic syndrome.
  • Bariatric surgery has shown potential for psoriasis improvement, possibly via GLP-1 mechanisms.
  • Existing evidence includes case reports and small series, necessitating further investigation.

Purpose of the Study:

  • To investigate the clinical impact of bariatric surgery on psoriasis in obese patients.
  • To assess changes in psoriasis severity and medication requirements post-surgery.
  • To identify factors predicting psoriasis improvement after bariatric procedures.

Main Methods:

  • A cohort of 33 morbidly obese patients with psoriasis undergoing active medical treatment was identified.
  • Demographic data, preoperative/postoperative medication use, and body surface area affected (%ABSA) were analyzed.
  • Follow-up data, including excess weight loss (EWL), were collected at least 6 months post-surgery.

Main Results:

  • Nearly 40% of patients (39.4%) showed psoriasis improvement, with 30.3% experiencing medication downgrade and 26.1% a reduced %ABSA.
  • Significant excess weight loss (mean 48.7%) was achieved post-surgery.
  • Factors predicting improvement included older age at surgery, Roux-en-Y gastric bypass, and greater EWL.

Conclusions:

  • Bariatric surgery led to psoriasis improvement in a significant portion of the study cohort.
  • The degree of postoperative weight loss and the use of Roux-en-Y gastric bypass were associated with better outcomes.
  • Bariatric surgery represents a potential therapeutic option for managing psoriasis in obese individuals.