Multidrug resistant Fusarium keratitis.
P Antequera1, V Garcia-Conca2, C Martín-González1
1Servicio de Microbiología, Hospital Universitario San Juan, Alicante, España.
Archivos De La Sociedad Espanola De Oftalmologia
|December 3, 2014
Summary
Multiresistant Fusarium solani caused severe keratitis in a contact lens wearer, leading to corneal abscess and requiring eye enucleation despite antifungal treatment. Early diagnosis and aggressive therapy are crucial for managing this resistant fungal infection.
Area of Science:
- Ophthalmology
- Medical Mycology
Background:
- Contact lens wear is a significant risk factor for microbial keratitis.
- Fusarium species are common causes of fungal keratitis, particularly in tropical and subtropical regions.
Observation:
- A contact lens wearer presented with a deep corneal abscess.
- Corneal biopsy cultures identified a multiresistant strain of Fusarium solani.
Findings:
- The patient experienced a complicated clinical course with poor response to standard antifungal treatments.
- Despite aggressive local and systemic antifungal therapy, the infection progressed, necessitating enucleation.
Implications:
- Fusarium keratitis can lead to severe outcomes, including endophthalmitis and vision loss.
- The high resistance of some Fusarium strains to conventional antifungal drugs complicates treatment strategies.
- Prompt clinical suspicion and initiation of appropriate antifungal therapy are critical for successful management of fungal keratitis.
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