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Skin cancer and new treatment perspectives: a review
M C F Simões1, J J S Sousa1, A A C C Pais2
1Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal.
Abstract:
Skin cancers are by far the most common malignancy of humans, particularly in the white population. The growing incidence of cutaneous malignancies has heralded the need for multiple treatment options. Although surgical modalities remain the mainstay of treatment, new research and fresh innovation are still required to reduce morbidity and mortality. Approaches for skin cancer may pass through new technological methods instead of new molecules. The first part of this paper provides a review of the state of the art regarding skin cancer disease as well as epidemiology data. Then, it describes the gold standards of the current recommended therapies worldwide and the actual needs of these patients. This is the first paper that highlights the novel and future therapeutic perspectives for the treatment of skin malignancies, new therapeutic agents and promising technological approaches, from nanotechnology to immunotherapy.
Insights
New research is needed to improve skin cancer treatment options beyond surgery. This review explores current therapies and future technological advancements like nanotechnology and immunotherapy for cutaneous malignancies.
Area of Science:
- Oncology
- Dermatology
- Biotechnology
Background:
- Skin cancers represent the most prevalent human malignancies, particularly in fair-skinned populations.
- Rising incidence rates necessitate diverse and innovative therapeutic strategies.
- Current treatments, while effective, require enhancement to minimize patient morbidity and mortality.
Purpose of the Study:
- To review the current landscape of skin cancer, including epidemiology and standard treatments.
- To identify unmet patient needs in cutaneous malignancy care.
- To highlight novel and emerging therapeutic technologies for skin cancer treatment.
Main Methods:
- Comprehensive literature review of skin cancer epidemiology and current therapeutic standards.
- Analysis of existing treatment modalities and patient care gaps.
- Exploration of cutting-edge technological approaches, including nanotechnology and immunotherapy.
Main Results:
- The paper reviews the current state of skin cancer, its epidemiology, and established treatments.
- It identifies critical needs and limitations in current patient management.
- Novel therapeutic perspectives, including technological innovations, are presented.
Conclusions:
- Surgical interventions remain primary, but innovation is crucial for better outcomes.
- Future skin cancer treatment may rely more on technological advancements than solely on new drugs.
- Nanotechnology and immunotherapy show significant promise for future skin cancer therapies.
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