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Left ventricular mechanical function: clinical correlates, heritability, and association with parental heart failure
Susan Cheng1, Elizabeth L McCabe, Martin G Larson
1Framingham Heart Study, Framingham, MA, USA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
European Journal of Heart Failure
|December 3, 2014
Summary
Cardiac mechanical function measures, like left ventricular (LV) strain, have genetic links and are influenced by clinical factors. Parental heart failure may predict worse LV strain in offspring.
Area of Science:
- Cardiology
- Genetics
- Echocardiography
Background:
- Non-invasive cardiac mechanical function measures show promise as heart failure risk markers.
- Limited data exist on clinical correlates and heritability of these measures in community settings.
Purpose of the Study:
- To investigate clinical correlates and heritability of left ventricular (LV) mechanical function using speckle-tracking echocardiography.
- To explore the association between parental heart failure and offspring LV mechanical function.
Main Methods:
- Speckle-tracking echocardiography assessed LV strain and synchrony in 2816 participants of the Framingham Offspring Study.
- Multivariable regression analyses identified clinical correlates of LV mechanical function.
- Heritability estimates (h²) and parental heart failure associations were examined.
Main Results:
- Male gender, higher heart rate, and cardiovascular disease were linked to worse global LV strains.
- Higher diastolic blood pressure, diabetes, and body mass index were associated with specific strain patterns.
- Longitudinal (h²=16%), transverse (h²=15%), and circumferential (h²=30%) LV strains showed significant heritability.
- Parental heart failure was associated with worse offspring circumferential strain (P=0.01).
Conclusions:
- Clinical correlates explain a small portion (4-19%) of variation in LV mechanical function.
- Significant heritability was found for key LV strain measures, indicating a genetic component.
- Parental history of heart failure is associated with impaired LV mechanical function in offspring.
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