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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Crystal coating via spray drying to improve powder tabletability.

V Vanhoorne, E Peeters, B Van Snick

    European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
    |December 3, 2014
    PubMed
    Summary

    A new crystal coating method improves powder flow and tablet formation. This spray drying technique enhances paracetamol (acetaminophen) powder properties for better tablet manufacturing.

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    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Poor flowability and high capping tendency of powders like paracetamol (acetaminophen) hinder tablet manufacturing.
    • Conventional methods often struggle to effectively improve these critical powder properties.

    Purpose of the Study:

    • To develop and evaluate a continuous crystal coating coprocessing method.
    • To enhance the flowability and tabletability of powders, specifically paracetamol.

    Main Methods:

    • A novel spray drying technique involving the introduction of solid particles into an atomized spray.
    • Coating and agglomeration of individual particles to improve powder characteristics.
    • Evaluation of particle size enlargement, flowability, and tablet compression properties.

    Main Results:

    • The crystal coating coprocessing method successfully produced paracetamol powders (75%) with excellent tableting properties.
    • Tablets exhibited superior compression characteristics, including high tensile strength (1.9 MPa) and low friability (0.6%), without capping.
    • The method also improved directly compressible lactose, enhancing its tensile strength and friability.

    Conclusions:

    • The continuous crystal coating coprocessing method is effective for improving powder flowability and tabletability.
    • Coating paracetamol crystals with amorphous lactose and PVP via coprocessing significantly enhances tablet properties.
    • This technique offers a viable approach for producing directly compressible pharmaceutical ingredients.