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Related Concept Videos

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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Chemical imaging and solid state analysis at compact surfaces using UV imaging.

Jian X Wu1, Sönke Rehder2, Frans van den Berg3

  • 1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark.

International Journal of Pharmaceutics
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Multi-wavelength UV imaging non-destructively maps chemical distribution and solid-state forms of glibenclamide and excipients in compacts. This fast technique shows potential for real-time monitoring of critical quality attributes in pharmaceutical manufacturing.

Keywords:
GlibenclamideMultivariate curve resolutionMultivariate image analysisNIR imagingSolid state packingUV imaging

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Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry
  • Process Analytical Technology (PAT)

Background:

  • Solid-state characterization and chemical distribution are critical for drug product quality.
  • Non-destructive, real-time monitoring techniques are essential for pharmaceutical manufacturing.

Purpose of the Study:

  • To evaluate multi-wavelength UV imaging for visualizing chemical component distribution and solid-state forms.
  • To assess the potential of UV imaging as a process analytical technique for pharmaceutical compacts.

Main Methods:

  • Utilized fast, non-destructive multi-wavelength UV imaging.
  • Employed multivariate image analysis for data interpretation.
  • Used model compacts containing glibenclamide (amorphous and crystalline), microcrystalline cellulose, and magnesium stearate.

Main Results:

  • UV imaging effectively visualized the distribution of glibenclamide and excipients.
  • Results showed good agreement with hyperspectral Near-Infrared (NIR) imaging.
  • UV imaging successfully distinguished between glibenclamide and excipients and mapped glibenclamide's solid-state form.

Conclusions:

  • Multi-wavelength UV imaging is a rapid, non-invasive technique for analyzing chemical composition and solid-state forms.
  • This method has significant potential for real-time monitoring of critical quality attributes in pharmaceutical production.
  • UV imaging offers a valuable tool for pharmaceutical process development and quality control.