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Exploring the possible relationship between the drug release of Compritol®-containing tablets and its polymorph forms

Vincent Jannin1, Yvonne Rosiaux1, Jean Doucet2

  • 1Gattefossé SAS, 36 chemin de Genas 69804 Saint-Priest cedex, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 3, 2014
PubMed
Summary

Lipid polymorphism does not affect drug release from Compritol® 888 ATO tablets. Changes in drug release during storage are likely due to alterations in the lipid matrix structure, not changes in lipid crystal forms.

Keywords:
DissolutionGlyceryl behenateLipid matrixMicro X-ray diffractionPolymorphismSustained-release

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