[Current methods in genetic analysis : an approach for genetics-based preventive medicine].

Area of Science:

• Molecular Genetics
• Genomic Research
• Biotechnology

Context:

• The post-genomic era has seen rapid advancements driven by genome research.
• DNA arrays (gene chips) and Next Generation Sequencing (NGS) are key technologies accelerating innovation.
• These powerful tools are increasingly applied in large-scale scientific projects.

Purpose:

• To outline the evolution of molecular genetics methods.
• To present array and NGS technologies as major innovation drivers.
• To discuss applications in research, rare disease diagnosis, and screening approaches, including ethical considerations.

Summary:

• Introduces DNA arrays and NGS as pivotal methods in modern genetic analysis.
• Highlights their application in large-scale research projects.
• Notes limitations in broad disease prevention screening due to gene-environment complexity, with exceptions in pharmacogenetics and oncology.

Impact:

• Facilitates understanding of genetic analysis method development.
• Provides insights into the application of advanced genetic technologies in scientific research and diagnostics.
• Raises awareness of the complexities and ethical issues surrounding genetic population screening.