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Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
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Does menstrual cycle phase affect lung diffusion capacity during exercise?

Joshua R Smith1, Kelly R Brown1, Jill D Murphy1

  • 1Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, USA.

Respiratory Physiology & Neurobiology
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Lung diffusing capacity (DLCO) and capillary blood volume (VC) change during the menstrual cycle in women exercising at high intensities. These physiological measures are lower during the early-follicular phase compared to the mid-luteal phase.

Keywords:
ExerciseLung diffusion capacityMenstrual cyclePulmonary blood volume

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Area of Science:

  • Exercise Physiology
  • Reproductive Endocrinology

Background:

  • Resting lung diffusing capacity for carbon monoxide (DLCO) varies across the menstrual cycle, potentially due to changes in capillary blood volume (VC).
  • The impact of these menstrual cycle variations on DLCO and VC during exercise remains largely unexplored.

Purpose of the Study:

  • To investigate the influence of different menstrual cycle phases on DLCO and VC during maximal exercise.
  • To test the hypothesis that increased VC during the mid-luteal phase enhances DLCO during exercise.

Main Methods:

  • Eight healthy, normally menstruating females underwent maximal oxygen uptake (V˙O2max) testing on a treadmill.
  • DLCO and VC were measured using single-breath exhalation and indirect methods, respectively, during the early-follicular, late-follicular, and mid-luteal phases.
  • Metabolic data were collected using a breath-by-breath automated system.

Main Results:

  • DLCO was significantly lower during the early-follicular phase compared to the mid-luteal phase at 90% and 100% V˙O2max.
  • Capillary blood volume (VC) was significantly greater during the mid-luteal phase than the early-follicular phase at 80%, 90%, and 100% V˙O2max.
  • These findings indicate menstrual cycle phase influences DLCO and VC during strenuous exercise.

Conclusions:

  • Menstrual cycle phase significantly affects lung diffusing capacity and capillary blood volume during heavy exercise.
  • The mid-luteal phase is associated with higher DLCO and VC during maximal exercise compared to the early-follicular phase.