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Basophil Activation Test for Allergy Diagnosis
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Elevated B cell-activating factor (BAFF) in children with allergic rhinitis.

Wenlong Liu1, Changzhi Sun1, Xi Luo2

  • 1Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China.

International Journal of Pediatric Otorhinolaryngology
|December 3, 2014
PubMed
Summary

B cell-activating factor (BAFF) was significantly elevated in children with allergic rhinitis (AR), correlating with disease severity. This suggests BAFF may offer new therapeutic targets for AR treatment.

Keywords:
Allergic rhinitisB cell-activating factorChildrenDisease severityImmunoglobulin A

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Area of Science:

  • Immunology
  • Pediatrics
  • Allergy Research

Background:

  • Allergic rhinitis (AR) is a common condition in children.
  • The role of B cell-activating factor (BAFF) in AR pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the potential involvement of BAFF in pediatric allergic rhinitis.
  • To assess the correlation between BAFF levels, disease severity, and immunoglobulin A (IgA) in children with AR.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure nasal and serum BAFF levels.
  • Nasal lavage and serum samples were collected from 24 children with AR and 20 healthy controls.
  • The relationship between serum BAFF and serum IgA was analyzed in AR patients.

Main Results:

  • Nasal and serum BAFF levels were significantly higher in children with AR compared to controls (p<0.05).
  • Increased BAFF levels in AR children were significantly associated with greater disease severity (p<0.05).
  • A negative correlation was observed between serum BAFF and serum IgA levels in AR children (p<0.05).

Conclusions:

  • BAFF expression is elevated in children with allergic rhinitis and linked to disease severity.
  • These findings suggest BAFF's potential role in the pathophysiology of AR.
  • BAFF may represent a promising target for novel therapeutic strategies in pediatric AR.