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Published on: February 1, 2022
Label electrochemical immunosensor for prostate-specific antigen based on graphene and silver hybridized mesoporous
Yueyun Li1, Jian Han1, Runhai Chen1
1School of Chemical Engineering, Shandong University of Technology, Zibo 255049, People's Republic of China.
Abstract:
Prostate-specific antigen (PSA), as the specificity of prostate cancer markers, has been widely used in prostate cancer diagnosis and screening. In this study, we fabricated an electrochemical immunosensor for PSA detection using the amino-functionalized graphene sheet-ferrocenecarboxaldehyde composite materials (NH2-GS@FCA) and silver hybridized mesoporous silica nanoparticles (Ag@NH2-MCM48). Under optimal conditions, the fabricated immunosensor showed a wide linear range with PSA concentration (0.01-10.0ng·ml(-1)). Low detection limit (2pg·ml(-1)) proved the high sensitivity. In addition, the immunosensor possessed good stability and reproducibility. Moreover, the application to PSA analysis in serum samples yielded satisfactory results.
