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Candida glabrata meningitis and endocarditis: a late severe complication of candidemia

Claudia Colomba1, Marcello Trizzino1, Claudia Imburgia1

  • 1Dipartimento di Scienze per la Promozione della Salute e Materno Infantile, Università di Palermo, Palermo, Italy.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|December 3, 2014
PubMed

Insights

This case report details a rare instance of Candida glabrata meningitis and endocarditis in a patient with a prosthetic valve and aortic aneurysm. It highlights the antifungal resistance of this specific yeast in central nervous system infections.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Neurology

Background:

  • Disseminated Candida infections can affect multiple organ systems.
  • Prosthetic valves and aortic aneurysms are risk factors for serious infections.
  • Candida glabrata is an opportunistic fungal pathogen.

Observation:

  • A young woman presented with both meningitis and endocarditis.
  • She had a history of a prosthetic aortic valve and a dissecting thoraco-abdominal aortic aneurysm.
  • Candida glabrata was identified in cerebrospinal fluid cultures.

Findings:

  • This case represents an uncommon manifestation of Candida glabrata central nervous system infection.
  • Candida glabrata demonstrated intrinsic resistance to azole antifungal agents.
  • The yeast caused both meningitis and endocarditis in the patient.

Implications:

  • Highlights the importance of considering Candida glabrata in invasive fungal infections, especially in at-risk patients.
  • Underscores the challenges in treating Candida glabrata infections due to antifungal resistance.
  • Emphasizes the need for appropriate diagnostic and therapeutic strategies for invasive candidiasis.

Keywords:
Candida glabrataCandidemiaEndocarditisMeningitis

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