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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
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Databases and collaboration require standards for human stem cell research.

Nadia K Litterman1, Sean Ekins2

  • 1Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA.

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PubMed
Summary
This summary is machine-generated.

To improve stem cell research, we propose centralized, harmonized data repositories and minimum information standards. This fosters collaboration and leverages all research efforts for human health advancements.

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Genomics

Background:

  • Stem cell research holds immense potential for human health and commercialization.
  • Current research efforts face challenges in data capture and utilization.
  • A need exists for better data sharing and integration across the stem cell community.

Purpose of the Study:

  • To propose a plan for a more collaborative stem cell research environment.
  • To address gaps in exploiting past and current stem cell research findings.
  • To establish a framework for global stem cell data management and sharing.

Main Methods:

  • Proposing the creation of centralized or harmonized data repositories for academic and industrial stem cell groups.
  • Advocating for secure, selective data sharing mechanisms.
  • Recommending the development of minimum information about stem cell experiments (MIASCE) standards.

Main Results:

  • A proposed framework for a centralized stem cell data repository.
  • A strategy for secure and selective data sharing.
  • The identification of MIASCE as a key component for data standardization.

Conclusions:

  • Centralized data repositories and standardized information are crucial for advancing stem cell research.
  • Collaboration and data sharing are essential to fully leverage stem cell research for human health.
  • Implementing MIASCE will enhance data consistency and interoperability.