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Updated: Feb 21, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
Aurora-A kinase: potential tumor marker of osteosarcoma
Xiaozhong Zhu1, Jiong Mei, Zhiyuan Wang
1Department of Orthopedic Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China.
Abstract:
Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.
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