Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

6
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
6
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

5
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
5
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.5K
Neural Regulation01:37

Neural Regulation

45.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.2K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

16
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
16

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of the Addenbrooke's Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants.

Brain communications·2022
Same author

Are mutations in MAPT associated with GGT type III?

Neuropathology and applied neurobiology·2019
Same author

Predictors of survival and progression in behavioural variant frontotemporal dementia.

European journal of neurology·2018
Same author

Region- and Cell-specific Aneuploidy in Brain Aging and Neurodegeneration.

Neuroscience·2018
Same author

Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration.

Neuropathology and applied neurobiology·2017
Same author

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Movement disorders : official journal of the Movement Disorder Society·2017

Related Experiment Video

Updated: Apr 20, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

8.1K

Inflammation is genetically implicated in Parkinson's disease.

N Dzamko1, C L Geczy2, G M Halliday1

  • 1School of Medical Sciences, University of NSW, Sydney, NSW 2052, Australia; Neuroscience Research Australia, Randwick, NSW 2031, Australia.

Neuroscience
|December 3, 2014
PubMed
Summary

Inflammation is linked to Parkinson's disease (PD) pathogenesis, with genetic mutations in genes like LRRK2 and SNCA playing key roles. Understanding these gene functions offers insights into PD causes and immune system connections.

Keywords:
LRRK2TLRinflammationinnateparkinsynuclein

More Related Videos

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.8K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.6K

Related Experiment Videos

Last Updated: Apr 20, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

8.1K
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.8K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.6K

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Inflammation is associated with Parkinson's disease (PD) pathogenesis, but its role as a cause or consequence remains debated.
  • Genetic factors, including mutations in LRRK2, Parkin, SNCA, PINK1, and GBA, are implicated in both familial and sporadic PD.
  • Many identified PD-associated genes function in immune pathways, suggesting a link between PD and immune homeostasis.

Purpose of the Study:

  • To investigate the role of inflammation in Parkinson's disease pathogenesis.
  • To explore the function of PD-associated genes and their protein products.
  • To understand the relationship between PD, genetic factors, and immune system regulation.

Main Methods:

  • Review of existing literature on PD genetics and inflammation.
  • Analysis of gene mutations and variations linked to familial and sporadic PD.
  • Examination of protein functions encoded by PD-associated genes within immune pathways.

Main Results:

  • Genetic mutations in LRRK2, Parkin, SNCA, and PINK1 are causative for familial PD.
  • Common variations in LRRK2, SNCA, and GBA are risk factors for sporadic PD.
  • Evidence suggests PD-related genes are involved in immune regulation and inflammation.

Conclusions:

  • Understanding the altered functions of PD-associated genes is crucial for identifying disease causes.
  • The close association between PD and immune homeostasis is supported by the function of implicated genes.
  • Further research into the interplay between genetics and immunity is needed for PD insights.