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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Current management and long-term outcomes following chorioamnionitis
Clark T Johnson1, Azadeh Farzin2, Irina Burd3
1Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287, USA; Integrated Research Center for Fetal Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 217, Baltimore, MD 21287, USA.
Obstetrics and Gynecology Clinics of North America
|December 3, 2014
Summary
Chorioamnionitis, an amniotic cavity infection, requires prompt diagnosis and broad-spectrum antibiotic treatment to prevent severe short-term and long-term health consequences for both mother and infant.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Neonatology
Background:
- Chorioamnionitis involves active infection and inflammation within the amniotic cavity.
- Multiple pathologic organisms can precipitate this condition.
- Untreated or delayed treatment leads to significant maternal and neonatal morbidity.
Purpose of the Study:
- To review current diagnostic criteria for chorioamnionitis.
- To outline established treatment protocols, including antibiotic therapy.
- To discuss long-term sequelae from delayed diagnosis or inadequate treatment.
Main Methods:
- Literature review of recent studies on chorioamnionitis.
- Synthesis of diagnostic and treatment guidelines.
- Analysis of outcomes associated with disease management.
Main Results:
- Early detection and broad-spectrum antibiotic administration are crucial.
- Effective management mitigates immediate and future complications.
- Incomplete treatment or delayed diagnosis results in adverse sequelae.
Conclusions:
- Chorioamnionitis necessitates prompt identification and intervention.
- Further research is needed to elucidate disease mechanisms.
- Developing improved detection and treatment strategies is essential to reduce associated morbidity.
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