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High sensitive C-reactive protein (hsCRP), cardiovascular events and mortality in the aged: a prospective 9-year

Marikka Kuoppamäki1, Marika Salminen2, Tero Vahlberg3

  • 1Institute of Clinical Medicine, Family Medicine, University of Turku, Turku, Finland; Naantali Health Centre, Naantali, Finland.

Archives of Gerontology and Geriatrics
|December 3, 2014
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) did not predict vascular disease events in older adults. While hsCRP predicted all-cause mortality, it did not add value beyond conventional risk factors.

Area of Science:

  • Cardiology
  • Gerontology
  • Biomarkers

Background:

  • High-sensitivity C-reactive protein (hsCRP) is a marker of inflammation.
  • Its role in predicting vascular disease (VD) and mortality in older adults needs further investigation.
  • Existing research on hsCRP and cardiovascular outcomes in the elderly is limited.

Purpose of the Study:

  • To assess the clinical utility of hsCRP categorization in older adults.
  • To determine if elevated hsCRP adds predictive value for cardiovascular morbidity and all-cause mortality beyond conventional risk factors.
  • To investigate the association between hsCRP levels and vascular disease events in individuals aged 64 and above.

Main Methods:

  • Prospective population-based study with a 9-year follow-up.
  • Included 771 participants aged 64+ without prior VD and with C-reactive protein (CRP) <10 mg/L at baseline.
  • Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for VD events and all-cause mortality based on hsCRP levels.

Main Results:

  • hsCRP was not significantly associated with incident VD events after adjusting for age, gender, VD risk factors, or metabolic syndrome.
  • hsCRP predicted all-cause mortality after adjustments for age and gender, but not independently of conventional risk factors.
  • Participants with high hsCRP (3.0-9.9 mg/L) showed increased age- and gender-adjusted mortality and a trend towards higher risk factor-adjusted mortality compared to low-risk individuals (hsCRP <1 mg/L).

Conclusions:

  • hsCRP categorization may not be clinically useful for predicting cardiovascular events in older adults.
  • Elevated hsCRP levels do not appear to provide additive predictive value for vascular events beyond established risk factors.
  • hsCRP's association with all-cause mortality in the elderly warrants further investigation but does not independently predict outcomes.
Abstract

Keywords:
AgedHigh sensitive C-reactive proteinRisk factorsVascular disease

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