Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

4
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
4
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

2.0K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
2.0K
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

5
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
5
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

2
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
2
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.7K
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

14
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
14

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HeatTracking: monitoring heat-related symptoms in the community through participatory self-reporting.

International journal of environmental health research·2026
Same author

Impact of age, cardiorespiratory fitness, and regular physical activity on physiological strain and cognitive performance during a 6-h extreme heat exposure.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Heat Exposure and Hospital Admissions for Mental Health Disorders in a Changing Climate.

Journal of the American Academy of Child and Adolescent Psychiatry·2026
Same author

The 2026 Europe report of the Lancet Countdown on health and climate change: narrowing window for decisive health action.

The Lancet. Public health·2026
Same author

Influence of age and biological sex on sweating in children exercising in warm and hot environments with comparison to adults.

The Journal of physiology·2026
Same author

Deadly heat stress conditions are already occurring for submission to Nature Communications.

Nature communications·2026
Same journal

The co-existence of Ehlers-Danlos syndrome and postural orthostatic tachycardia syndrome: A systematic review of the literature.

Autonomic neuroscience : basic & clinical·2026
Same journal

Urodynamics and what they reveal about autonomic innervation of the lower urinary tract: A narrative review.

Autonomic neuroscience : basic & clinical·2026
Same journal

Pelvic venous disorders and orthostatic intolerance: A systematic review of diagnostic associations and treatment outcomes.

Autonomic neuroscience : basic & clinical·2026
Same journal

Application of heart rate variability in clinical practice and research: A systematic review of recent years.

Autonomic neuroscience : basic & clinical·2026
Same journal

Spinal afferent endings in the gastrointestinal tract.

Autonomic neuroscience : basic & clinical·2026
Same journal

Gastric myoelectrical activity and autonomic dysfunction in children with IBD and IBS: An electrogastrographic and autonomic correlation study.

Autonomic neuroscience : basic & clinical·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.5K

Autonomic dysfunction in multiple sclerosis: implications for exercise.

Mu Huang1, Ollie Jay2, Scott L Davis3

  • 1Department of Applied Physiology & Wellness, Southern Methodist University, Dallas, TX, United States.

Autonomic Neuroscience : Basic & Clinical
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) causes autonomic dysfunction, impairing blood pressure and sweating during exercise. This limits exercise capacity and may require new therapeutic strategies for improved quality of life.

Keywords:
Blood pressureCardiovascularDemyelinationSweatSympathetic nerve activityThermoregulation

More Related Videos

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
08:07

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Published on: February 1, 2018

13.4K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K

Related Experiment Videos

Last Updated: Apr 20, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.5K
Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
08:07

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Published on: February 1, 2018

13.4K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K

Area of Science:

  • Neurology
  • Exercise Physiology
  • Autonomic Neuroscience

Background:

  • Multiple sclerosis (MS) is a progressive neurological disorder impacting autonomic nervous system function.
  • Autonomic dysfunction in MS affects cardiovascular and thermoregulatory control, particularly during physical activity.
  • Impaired autonomic responses can lead to reduced skeletal muscle blood flow and compromised heat dissipation during exercise.

Purpose of the Study:

  • To investigate the physiological mechanisms underlying autonomic dysfunction during exercise in individuals with multiple sclerosis.
  • To understand how autonomic impairments affect cardiovascular responses and thermoregulation in MS patients during physical exertion.
  • To identify potential therapeutic targets for mitigating exercise limitations in MS.

Main Methods:

  • The study involved assessing cardiovascular responses (e.g., blood pressure) during exercise in MS patients.
  • Thermoregulatory function, including sweating responses, was evaluated during exercise protocols.
  • Physiological data were analyzed to correlate autonomic function with exercise capacity and limitations.

Main Results:

  • MS patients exhibited attenuated blood pressure increases during exercise compared to controls.
  • Reduced sweating responses were observed in MS individuals, indicating impaired heat dissipation.
  • These autonomic impairments were linked to limitations in achievable exercise intensity and potential risks of overheating.

Conclusions:

  • Autonomic dysfunction significantly impacts exercise performance in multiple sclerosis by compromising cardiovascular support and thermoregulation.
  • Understanding these physiological deficits is crucial for developing interventions to improve exercise tolerance and quality of life for MS patients.
  • Targeted therapies addressing autonomic control during exercise may offer a promising avenue for managing MS symptoms.