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Allogeneic hematopoietic cell transplantation in adult patients with acute lymphoblastic leukemia

David I Marks1, Laura Alonso1, Rohini Radia1

  • 1Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK.

Hematology/Oncology Clinics of North America
|December 3, 2014
PubMed

This review discusses the use of prognostic factors, patient and donor selection, choice of conditioning regimens, and timing of transplant. It also describes the management of Philadelphia-positive acute lymphocytic leukemia (ALL) and central nervous system disease. All aggressively treated adults with ALL should be considered for allogeneic transplantation and tissue typed at diagnosis. We further suggest that eligible patients be entered into clinical trials (that incorporate transplantation); these unselected prospective outcome data are essential to evaluate the true value of allogeneic transplantation in adults with ALL.

Keywords:
Acute lymphoblastic leukemiaAllogeneic hematopoietic cell transplantationPretransplant conditioningPrognostic factorsTiming of transplant

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