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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

7
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
7
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

4
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
4
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

475
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
475
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

6
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
6
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

5
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
5
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

2
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
2

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Endovascular stroke intervention in the very young.

Mario Zanaty1, Nohra Chalouhi1, Robert M Starke2

  • 1Department of Neurosurgery, Thomas Jefferson University, Philadelphia, USA.

Clinical Neurology and Neurosurgery
|December 3, 2014
PubMed
Summary

Endovascular therapy effectively treats acute ischemic stroke in young patients with large vessel occlusion, showing high recanalization and favorable outcomes with few complications. This approach supports aggressive management for this demographic.

Keywords:
Endovascular therapyLarge vessel occlusionStrokeYoung

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Interventional Neurology

Background:

  • Acute ischemic stroke (AIS) in young patients (≤ 35 years) with large vessel occlusion (LVO) presents unique challenges.
  • Endovascular therapy has emerged as a critical treatment modality for AIS.

Purpose of the Study:

  • To evaluate the safety and efficacy of endovascular therapy in very young patients (≤ 35 years) with AIS due to LVO.
  • To assess recanalization rates and functional outcomes in this specific patient population.

Main Methods:

  • Retrospective analysis of a prospectively maintained database from two cerebrovascular referral centers.
  • Inclusion criteria: young patients (≤ 35 years) with confirmed LVO undergoing endovascular intervention.
  • Modified Rankin Scale (mRS) assessed at 90 days post-intervention.

Main Results:

  • Fifteen young patients (mean age 27.93 years) were included.
  • High successful recanalization rate (TICI 2-3) in 93.33% of patients.
  • Favorable 90-day outcome (mRS 0-2) achieved in 86.67% of patients with limited hemorrhagic complications (6.67%).

Conclusions:

  • Endovascular therapy is a safe and effective treatment for very young patients with AIS and LVO.
  • High rates of recanalization and favorable functional outcomes can be achieved.
  • Aggressive endovascular management strategies are supported for this patient group.