Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MAD-MT Score: A Tool to Optimize Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions.

Stroke·2026
Same author

Initial Experience With a Deep Learning Algorithm for Detecting Posterior Circulation Large Vessel Occlusion on Noncontrast Computed Tomography.

Stroke (Hoboken, N.J.)·2026
Same author

Standardizing Global Pediatric Stroke Pathways: Insights From a Global Survey Conducted by the Society of Neurointerventional Surgery Pediatric Special Interest Group.

Stroke (Hoboken, N.J.)·2026
Same author

Final Infarct Volume as a Surrogate End Point in Anterior Circulation ICAS-LVO Stroke: Post Hoc Secondary Analysis of RESCUE-ICAS.

Stroke (Hoboken, N.J.)·2026
Same author

Defining Social and Cultural Barriers to Global Stroke Care: A SVIN-Mission Thrombectomy Initiative.

Stroke (Hoboken, N.J.)·2026
Same author

Sex-Specific Association Between Socioeconomic Status and Stroke Mortality.

Journal of the American Heart Association·2026
Same journal

Angioarchitectural predictors of failed endovascular treatment in high-grade dural arteriovenous fistulas.

Journal of neurointerventional surgery·2026
Same journal

Clopidogrel versus ticagrelor in dual antiplatelet therapy for flow diversion of unruptured intracranial aneurysms: analysis of the Neurovascular Quality Initiative-Quality Outcomes Database (NVQI-QOD) Cerebral Aneurysm Registry.

Journal of neurointerventional surgery·2026
Same journal

SQUID embolization for cerebral AVMs: 1-year safety and efficacy results from the CHOICE prospective multicenter study.

Journal of neurointerventional surgery·2026
Same journal

Post-thrombectomy angiography-derived fractional flow is associated with functional outcomes in ICAS-related large vessel occlusion.

Journal of neurointerventional surgery·2026
Same journal

Deep inspiration-facilitated stenting for extremely tortuous vertebral artery ostium in a Type III arch.

Journal of neurointerventional surgery·2026
Same journal

Ticagrelor for CYP2C19 loss-of-function carriers undergoing intracranial aneurysm stenting.

Journal of neurointerventional surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Yttrium-90 Radioembolization for Recurrent Meningioma: Rationale and Roadmap for Neurointerventional Translation.

Aaron Daniel Brake1, Kevin John2, Sanchay Jain3

  • 1Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Journal of Neurointerventional Surgery
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Transarterial radioembolization (TARE) is a viable treatment for difficult meningiomas. This approach uses radioactive microspheres delivered via the tumor's blood supply, offering a new option for recurrent or inoperable cases.

Keywords:
EmbolicNeoplasmTechnologyTumor

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique
09:08

Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jun 4, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique
09:08

Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique

Published on: March 15, 2024

Area of Science:

  • Neuro-oncology
  • Interventional Radiology
  • Nuclear Medicine

Background:

  • Meningiomas often require surgery or radiotherapy, but effective treatments for recurrent or inoperable tumors, especially higher-grade ones, are limited.
  • Intra-arterial yttrium-90 (90Y) transarterial radioembolization (TARE) is an established technique for liver cancer, delivering targeted beta-brachytherapy using radioactive microspheres.
  • The distinct dural arterial supply of meningiomas suggests TARE could be adapted for treating these brain tumors.

Purpose of the Study:

  • To evaluate the plausibility of adapting transarterial radioembolization (TARE) for treating intracranial meningiomas.
  • To review existing literature and adjacent fields to inform the potential application of TARE in meningioma management.
  • To identify key considerations for designing early-phase clinical trials of TARE for meningiomas.

Main Methods:

  • Systematic literature searches of PubMed and Google Scholar were conducted for intracranial TARE planning and delivery.
  • A scoping review of related fields, including meningioma radionuclide therapy, PRRT, hepatic TARE, and embolization techniques, was performed.
  • Radiobiology relevant to meningioma vascularity, dosimetry, hypoxia, and imaging was also reviewed.

Main Results:

  • Limited direct studies (five publications, one ongoing trial) exist for intracranial TARE, but supporting literature is extensive.
  • Two TARE platforms (glass and resin microspheres) differ in dose and density, impacting delivery.
  • Meningiomas' compartmentalized dural supply facilitates catheter access and potential single-compartment dosimetry, with generally low shunting risk; TARE may achieve higher radiation doses than current radioligand therapies.

Conclusions:

  • Transarterial radioembolization (TARE) is a plausible treatment for recurrent and inoperable meningiomas due to their vascular characteristics.
  • Key considerations for TARE trial design include microsphere selection, treatment territory (external vs. internal carotid arteries), dosimetry based on meningioma angiosomes, and a safety framework addressing non-target deposition and radiation necrosis.