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Updated: Apr 20, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
Pitfalls in the application of gene-set analysis to genetics studies
Abstract:
Gene-set analysis (GSA) (‘enrichment’) is a popular approach for the interpretation of genome-wide association studies (GWASs). GSA is most commonly applied to the analysis of transcriptomes, but from the outset it has been considered useful for any study that provides rankings or ‘hit lists’ of genes. The recent review by Mooney et al. [1] is a valuable resource for geneticists wishing to apply GSA to the output of GWASs. Here we describe some additional points of practical importance if the methods are to be applied and interpreted soundly.
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