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Updated: Apr 20, 2026

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity
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Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity

Published on: December 31, 2015

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Response to pathological processes in the peritoneal cavity--sepsis, tumours, adhesions, and ascites

Martijn W J Stommel1, Chema Strik1, Harry van Goor1

  • 1Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Seminars in Pediatric Surgery
|December 3, 2014
PubMed

Insights

Pediatric peritoneal inflammation involves complex pathways affecting common surgical sites. Understanding these responses offers new therapeutic targets for conditions like sepsis and metastasis.

Area of Science:

  • Pediatric surgery
  • Peritoneal pathology
  • Inflammatory pathways

Background:

  • The peritoneum is frequently involved in pediatric surgical pathologies.
  • Peritoneal response to injury involves specific inflammatory pathways.
  • Common conditions include inflammation, adhesion, sepsis, metastasis, and ascites.

Purpose of the Study:

  • To review the current understanding of peritoneal inflammation in pediatric surgery.
  • To discuss adhesion formation, intra-abdominal sepsis, peritoneal metastasis, and ascites.
  • To briefly review novel therapeutic strategies for these conditions.

Main Methods:

  • Literature review of recent studies on peritoneal responses.
  • Synthesis of current knowledge on peritoneal inflammation and related pathologies.
  • Overview of emerging therapeutic targets and strategies.

Main Results:

  • Improved understanding of the specific pathways involved in peritoneal inflammation.
  • Identification of key pathological entities: adhesion, sepsis, metastasis, ascites.
  • Emergence of new potential therapeutic targets based on recent research.

Conclusions:

  • Recent research has significantly advanced the understanding of pediatric peritoneal responses.
  • This enhanced knowledge provides new avenues for preventing and treating peritoneal pathologies.
  • Further investigation into these targets may lead to improved patient outcomes.

Keywords:
AdhesionsAscitesInflammatory responsePeritoneal metastasisPeritoneumSepsis

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