Predictive and prognostic value of circulating tumor cell detection in lung cancer: a clinician's perspective
Annette Tognela1, Kevin J Spring2, Therese Becker2
1Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; Macarthur Clinical School, University of Western Sydney, Campbelltown 2560, Australia; Department of Medical Oncology, Campbelltown Hospital, Campbelltown 2560, Australia.
Abstract:
There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.
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