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Updated: Feb 13, 2026

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
Published on: May 19, 2021
Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion
1Department of Medicine, Indiana University School of Medicine, Indianapolis.
Abstract:
Beta-adrenergic agonists have been shown to stimulate aldosterone secretion. Angiotensin II (AII) is one of the important stimuli of aldosterone secretion; conceivably beta-adrenergic influences affect the stimulatory potential of AII. Using cultured rat adrenal capsules, we found that 10(-7) M epinephrine and 10(-7) M isoproterenol enhanced 10(-7) M AII-stimulated aldosterone production. Propranolol (10(-7) M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII. In conclusion, beta-adrenergic agonists promote stimulation of aldosterone secretion by AII.
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