Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Peripheral neuropathies caused by drugs].

P A Uldry, F Regli

    Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
    |June 6, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Cervicogenic headaches].

    Revue medicale suisse·2006
    Same author

    Heralding manifestations of basilar artery occlusion with lethal or severe stroke.

    Journal of neurology, neurosurgery, and psychiatry·2003
    Same author

    A phase II trial with new triptorelin sustained release formulations in prostatic carcinoma.

    International urology and nephrology·2002
    Same author

    [Neurologic emergencies in the physician's office].

    Revue medicale de la Suisse romande·2000
    Same author

    [Making use of mortality statistics in the treatment of stroke].

    Revue medicale de la Suisse romande·2000
    Same author

    Effects of proximal and distal muscles' groups contraction and mental stress on the amplitude and frequency of physiological finger tremor. An accelerometric study.

    Electromyography and clinical neurophysiology·2000

    Chemotherapy drugs can cause peripheral neuropathy, a nerve damage affecting long nerves and resulting in symmetrical sensory loss. Other medications and vitamin abuse can also lead to this condition.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Oncology

    Context:

    • Peripheral neuropathy is a frequent adverse effect of various medications.
    • Chemotherapeutic agents are a significant cause of drug-induced peripheral neuropathy.
    • This condition primarily affects long axons, leading to distal axonal degeneration.

    Purpose:

    • To review the mechanisms and clinical presentation of drug-induced peripheral neuropathy.
    • To highlight the neurotoxic effects of common chemotherapeutic agents like cisplatin and vinca alkaloids.
    • To discuss other causative agents, including antimicrobials and vitamin abuse.

    Summary:

    • Drug-induced peripheral neuropathy commonly manifests as a symmetrical sensory neuropathy.
    • Distal axonal degeneration of long axons is the predominant pathological feature.

    Related Experiment Videos

  • Key culprits include chemotherapy drugs (cisplatin, vinca alkaloids), antimicrobials (isoniazid, nitrofurantoin), and excessive pyridoxine.

    • Impact:

    • Informing clinicians about the risks of neurotoxicity from specific therapeutic agents.
    • Improving patient monitoring and management strategies for peripheral neuropathy.
    • Contributing to the development of neuroprotective approaches in chemotherapy and other treatments.