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Updated: Apr 20, 2026
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Maternal lead exposure and risk of congenital heart defects occurrence in offspring
Zhen Liu1, Yu Yu2, Xiaohong Li3
1National Centre for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Maternal lead exposure may be harmful to fetal development. However, sufficient evidence was lacked about the risk on cardiac development in offspring. To explore the association between maternal lead exposure and risks of congenital heart defects (CHDs) occurrence in fetuses, a case-control study was adopted during pregnant women making antenatal examinations. The maternal hair lead levels were measured by using inductively coupled plasma mass spectrometry (ICP-MS), and logistic regression analysis was used to calculate the odds ratio (OR). Three hundred and sixteen cases and 348 controls were eligible to the study. The median level of lead in maternal hair of case (0.670ng/mg) was significantly higher (AOR 3.07, 95% CI 2.00-4.72) than that of the control (0.461ng/mg), including the CHD cases with or without extracardiac malformations (AOR 3.55, 2.94, respectively). Maternal lead exposure is associated with the risk of some subtypes of CHDs occurrence in offspring. The potential dose-response relationship is also presented.
Maternal lead exposure may be harmful to fetal development. However, sufficient evidence was lacked about the risk on cardiac development in offspring. To explore the association between maternal lead exposure and risks of congenital heart defects (CHDs) occurrence in fetuses, a case-control study was adopted during pregnant women making antenatal examinations. The maternal hair lead levels were measured by using inductively coupled plasma mass spectrometry (ICP-MS), and logistic regression analysis was used to calculate the odds ratio (OR). Three hundred and sixteen cases and 348 controls were eligible to the study. The median level of lead in maternal hair of case (0.670ng/mg) was significantly higher (AOR 3.07, 95% CI 2.00-4.72) than that of the control (0.461ng/mg), including the CHD cases with or without extracardiac malformations (AOR 3.55, 2.94, respectively). Maternal lead exposure is associated with the risk of some subtypes of CHDs occurrence in offspring. The potential dose-response relationship is also presented.
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