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[Neutralizing activity against herpes simplex in maternal milk].

I Lopez1, M Quibriac, J Petitjean

  • 1Laboratoire de Virologie, CHRU de Caen.

Archives Francaises De Pediatrie
|April 1, 1989
PubMed
Summary

Human milk may offer some protection against Herpes simplex virus 2 (HSV-2) infection in newborns. However, the weak neutralizing activity found in milk was not linked to HSV-2 antibodies or maternal serum activity.

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[Human coronaroviruses].

Virologie (Montrouge, France)·2021

Area of Science:

  • Virology
  • Immunology
  • Neonatal Health

Context:

  • Herpes simplex virus 2 (HSV-2) poses a risk to newborns.
  • Human milk is a potential source of passive immunity for infants.
  • Understanding milk's protective factors against viral infections is crucial.

Purpose:

  • To investigate the presence and nature of neutralizing activity against HSV-2 in human milk.
  • To determine if this activity correlates with anti-HSV-2 antibodies or maternal serum neutralizing capacity.

Summary:

  • Neutralizing activity against HSV-2 was assessed in 94 human milk samples and 31 maternal sera.
  • Weak neutralizing activity was detected in 48% of milk samples.
  • This activity showed no correlation with milk-borne anti-HSV-2 antibodies or serum neutralizing activity, suggesting a non-immunologic origin.

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Impact:

  • Highlights a potential, yet uncharacterized, protective factor in human milk against HSV-2.
  • Suggests that traditional antibody-based immunity may not fully explain milk's antiviral properties.
  • Warrants further research into the non-immunologic components of human milk with antiviral potential.