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Bio-Chemo-Mechanical Models of Vascular Mechanics
Jungsil Kim1, Jessica E Wagenseil
1Department of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.
Annals of Biomedical Engineering
|December 4, 2014
Summary
Understanding vascular mechanics requires advanced models. This review covers bio-mechanical and bio-chemo-mechanical models for arteries, highlighting their applications and future challenges in vascular disease research.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Computational Biology
Background:
- Classic arterial models lack physical component association.
- Microstructurally-linked models connect wall components to tissue mechanics.
- Vascular disease involves chemical signaling affecting artery biology and mechanics.
Purpose of the Study:
- To review bio-mechanical and bio-chemo-mechanical models of vascular mechanics.
- To focus on models relevant to large elastic arteries.
- To discuss applications and future challenges in modeling arterial behavior.
Main Methods:
- Literature review of existing bio-mechanical models.
- Analysis of microstructurally-linked models.
- Inclusion of bio-chemo-mechanical models incorporating chemical signaling.
Main Results:
- Phenomenological models are limited by non-physical parameters.
- Microstructurally-linked models offer better correlation with pathological changes.
- Bio-chemo-mechanical models are essential for comprehensive vascular mechanics.
Conclusions:
- Advanced bio-chemo-mechanical models are critical for predicting arterial response.
- These models are vital for developing targeted treatments for vascular diseases.
- Further research is needed to address challenges in bio-chemo-mechanical modeling of arteries.
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