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Updated: Apr 20, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
α-Ketoamino acid ester derivatives as promising MAO inhibitors
Ayman El-Faham1, Zainab Al Marhoon, Ahmed Abdel-Megeed
1Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia. aymanel_faham@hotmail.com
Abstract:
α-Ketoamino acid ester 2-[2-(2-acetamidophenyl)-2-oxoacetamido] and 2-[4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido] derivatives were synthesized via the ring opening of N-acetylisatin under mild conditions. These compounds were then examined for their capacity to inhibit monoamine oxidase (MAO). The inhibition profile was found to be competitive for compounds 4d, 6a, 6b and 6f, which showed MAO-A selectivity. Observation of the docked positions of these compounds revealed interactions with many residues previously reported to have an effect on the inhibition of the enzyme. Our findings indicate that the members of this family of α-ketoamino acid esters are promising MAO inhibitors.
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