Could physical exercises modulate Nrf2-Keap1 pathway in chronic kidney disease?

Area of Science:

• Nephrology
• Molecular Biology
• Exercise Physiology

Background:

• Chronic kidney disease (CKD) is associated with metabolic disorders, oxidative stress, and inflammation.
• Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular defense against oxidative stress and inflammation.
• Nrf2 activation leads to the expression of antioxidant and detoxifying enzymes.

Purpose of the Study:

• To review the existing evidence on the correlation between physical activity and Nrf2 expression in CKD patients.
• To assess the potential of physical exercise as a non-pharmacological strategy to activate the Nrf2 pathway in CKD.
• To determine if physical exercise can be recommended for CKD patients to modulate Nrf2-mediated cellular protection.

Main Methods:

• Literature review of studies investigating Nrf2 modulation by bioactive compounds and physical exercise.
• Analysis of research on the benefits of exercise in CKD patients.
• Examination of the mechanistic links between physical activity and the Nrf2 pathway.

Main Results:

• Nrf2 expression can be modulated by factors including bioactive compounds and physical exercise.
• Physical exercise offers numerous benefits for patients with CKD.
• Currently, there is a lack of studies directly correlating physical activity with Nrf2 expression in the CKD population.

Conclusions:

• Physical exercise shows promise as a non-pharmacological intervention for CKD patients.
• Activating the Nrf2 pathway through exercise could offer a novel therapeutic strategy.
• Further research is needed to establish a direct link and provide evidence-based recommendations for exercise in CKD to target Nrf2.