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Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Karina M Mata1, Cristiane Tefé-Silva1, Elaine M Floriano1

  • 1Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|December 4, 2014
PubMed
Abstract

Insights

Doxycycline pretreatment significantly reduced abdominal aortic aneurysm (AAA) development in rats by inhibiting matrix metalloproteinase (MMP) activity and inflammation. This suggests doxycycline

Area of Science:

  • Vascular Biology
  • Pharmacology

Background:

  • Abdominal aortic aneurysm (AAA) involves inflammation and extracellular matrix degradation by matrix metalloproteinases (MMPs).
  • Doxycycline is known to modulate MMP activity and influence AAA progression.

Purpose of the Study:

  • To investigate the effect of doxycycline pretreatment on AAA formation in a rat model.
  • To assess doxycycline's impact on MMP-2 and MMP-9 activity and inflammatory responses.

Main Methods:

  • Male Wistar rats were divided into aneurysm and control groups, with doxycycline pretreatment administered to respective subgroups.
  • AAA was induced via aortic wall injury and stenosis.
  • Morphological analyses, immunohistochemistry, and zymography were performed at various time points post-surgery.

Main Results:

  • Doxycycline treatment led to an 85% reduction in AAA development compared to untreated aneurysm groups.
  • A significant decrease in gelatinolytic activity of MMP-2 and MMP-9 was observed.
  • Reduced inflammatory responses were noted in doxycycline-treated animals.

Conclusions:

  • Doxycycline pretreatment effectively inhibits MMP-2 and MMP-9 activity.
  • This inhibition, along with reduced inflammation, suggests doxycycline's potential role in preventing AAA development.
Keywords:
Abdominal aortic aneurysmDoxycycline pretreatmentInflammatory responseMetalloproteinases 2 and 9

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