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Updated: Apr 20, 2026
A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
A co-clinical platform to accelerate cancer treatment optimization
Andrea Lunardi1, Pier Paolo Pandolfi1
1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
The Co-Clinical Trial Project uses genetically engineered mouse models to accelerate cancer research. This platform rapidly stratifies patients and identifies resistance mechanisms to improve cancer treatment strategies.
Area of Science:
- Oncology
- Genomics
- Translational Medicine
Background:
- Advances in DNA and RNA sequencing reveal cancer's complexity.
- Translating genomic discoveries into clinical practice for cancer patients is slow.
Purpose of the Study:
- To establish a translational platform for accelerating cancer research.
- To bridge the gap between preclinical findings and clinical application in oncology.
Main Methods:
- Implementation of 'The Co-Clinical Trial Project'.
- Utilizing genetically engineered mouse models (GEMMs) of human cancer.
- Aligning GEMM treatment protocols with human clinical trials or established therapies.
Main Results:
- Enables rapid patient stratification based on genetic and molecular markers.
- Facilitates identification of mechanisms underlying tumor resistance.
- Supports evaluation of drug combinations to overcome resistance.
Conclusions:
- The Co-Clinical Trial Project enhances the translation of cancer genomics into patient care.
- This platform accelerates the development of targeted cancer therapies.
- Mechanistic insights from GEMMs inform clinical strategies for overcoming drug resistance.
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